The acute oral LD50 of naphthalene was 533 and 710 mg/kg in male and female mice, respectively. In: Hygienic guide series. The lowest dose tested (50 mg/kg/day by gavage) was associated with signs of CNS depression for the first 3 days. Random bred CD-1 mice were used to evaluate the acute oral toxicity and subchronic toxicity of naphthalene administered in corn oil. Short-term exposure guidelines: None developed, Human data: The probable oral lethal dose has been reported to be between 5 and 15 grams [Gerarde 1960]. Noncarcinogenic Health Effects. doses (100, 200 mg/kg-day) arrived at a critical NOAEL/LOAEL pair of 71 and 143 mg/kg-day for decreased mean terminal body weight in male rats. Human data: The probable oral lethal dose has been reported to be between 5 and 15 grams [Gerarde 1960]. endstream endobj startxref DO NOT use it to treat or manage an actual poison exposure. Baltimore, MD: Williams & Wilkins Company, pp. Workers deficient in glucose-6-phosphate dehydrogenase are more susceptible to hemolysis. NAPHTHALENE, 1-METHYLNAPHTHALENE, AND 2-METHYLNAPHTHALENE . 5th ed. You will be subject to the destination website's privacy policy when you follow the link. Severe poisoning can result in haemolytic anaemia. The following is a presentation of the toxicity information associated with Naphthalene. It is best known as the main ingredient of traditional mothballs A gradual recovery in sensitivity to the 300 mg/kg challenge dose of naphthalene was observed as the time between the last 200 mg/kg naphthalene dose increased from 24 to 144 hr. Gerarde HW [1960]. This can cause organ damage. It is … from recent studies of naphthalene identified by literature searches conducted in 1999 and 2000 and the primary references for key studies. Gosselin RE, Smith RP, Hodge HC [1984]. CDC twenty four seven. $�A���b�$z�3?��$�bM3@�@�lK$� b��]:@�!HL�`d� �20R���x�#@� C|5 In contrast to the effect in mice, doses of naphthalene as high as 1600 mg/kg ip caused no detectable pulmonary or renal damage in the rat. CDC is not responsible for Section 508 compliance (accessibility) on other federal or private website. 3. Naphthalene orally administered to rats and rabbits induced no developmental toxicity at up to maternally toxic doses. Fundam Appl Toxicol 4:406-419. The chosen IDLH, therefore, has been estimated from the probable oral lethal dose of 5 to 15 grams for an adult [Gerarde 1960 cited by AIHA 1967]. Moscow, Russia: Centre of International Projects, GKNT, p. 89. The symptoms of naphthalene and paradichlorobenzene toxicity are different too. Naphthalene is a toxic substance that is available in the form of moth repellents, lavatory deodorizers, and compounds for industrial use; Note: The compound can interact with other prescribed or non-prescribed medications in the body. Developmental toxicity was expressed only as significant trends toward decreased fetal weight and increased incidence of visceral malformations in the naphthalene-treated groups. 53 0 obj <>/Filter/FlateDecode/ID[<936F875D222D164ABFAF9631AFB31C2D>]/Index[33 38]/Info 32 0 R/Length 93/Prev 94955/Root 34 0 R/Size 71/Type/XRef/W[1 2 1]>>stream Subchronic toxicity was evaluated with 14- and 90-day daily oral gavage studies. Therefore, if you’re going to buy mothballs, look for ones made from paradichlorobenzene. [Note: An oral dose between 5 and 15 grams is equivalent to a worker being exposed to about 600 to 1,800 ppm for 30 minutes, assuming a breathing rate of 50 liters per minute and 100% absorption.]. Data on establishing the maximum permissible concentration of naphthalene and chloronaphthalene in reservoir water. Toxicology and biochemistry of aromatic hydrocarbons. Therapeutics Index.
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